BICAN: Cell Census of Developing Brain
Molecular and cellular dynamics of the developing human neocortex
core
Authors
Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrián-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian Gomes de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li & Arnold R. Kriegstein
Citation
Wang, L., Wang, C., Moriano, J.A. et al. Molecular and cellular dynamics of the developing human neocortex. Nature (2025). https://doi.org/10.1038/s41586-024-08351-7
Summary
The study creates a single-cell multi-omic atlas of human neocortical development, identifying tripotential intermediate progenitors that generate GABAergic neurons, oligodendrocyte precursors, and astrocytes, and shows glioblastoma cells share their transcriptomic features. It also links second-trimester intratelencephalic neurons to increased autism risk.
Data and Tools
Resource Name | Resource URL | Description |
|---|---|---|
NeMO archive | https://assets.nemoarchive.org/dat-oiif74w | Data download: 988 files of raw and aligned snMultiome data. |
BIL archive | https://doi.org/10.35077/g.1156 | Data download: Raw and pre-processed MERFISH data. |
Interactive Portal | https://cell.ucsf.edu/snMultiome/ | Data exploration: Browse chromatin accessibility and MERSCOPE data. |
CELLxGENE | https://cellxgene.cziscience.com/collections/ad2149fc-19c5-41de-8cfe-44710fbada73 | Data visualization: Explore single cell data in CELLxGENE. |
Dryad | https://doi.org/10.5061/dryad.2280gb612 | Data download: 135.22 GB files of processed data. |
Project Page | https://knowledge.brain-map.org/data/SFNQPM0DRGGFBZBZC19 | Project Page in the BICAN Data Catalog |