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BICAN: Cell Census of Developing Brain

Lineage-resolved atlas of the developing human cortex

core

Matt G. Keefe, Marilyn R. Steyert, and Tomasz J. Nowakowski

Authors

Matt G. Keefe, Marilyn R. Steyert, and Tomasz J. Nowakowski

Citation

Keefe, M.G., Steyert, M.R., et al. Developmental lineage relationships of radial glial cells. Nature (2025) https://doi.org/10.1038/s41586-025-09033-8

Summary

This study utilizes barcoded lineage tracing to reveal a developmental switch from glutamatergic to GABAergic neurogenesis in the human cortex.

Data and Tools

Resource Name
Resource URL
Description
dbGap
https://dbgap.ncbi.nlm.nih.gov/beta/study/phs002624.v4.p1/#study
Data Download: dbgap dataset for human iPS line data.
UCSC
https://cortex-midgestation.cells.ucsc.edu/
Data Exploration: Cortex midgestation
Code
https://github.com/mattgkeefe/sticr_paper_code
Code Repository: Github repository for paper-related code.

The Brain Cell Data Center (BCDC) at the Allen Institute for Brain Science provides a foundational community resource on cell types in the mammalian brain by sharing the integrated data, tools, and knowledge produced by the BRAIN Initiative Cell Atlas Network (BICAN).

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