BICAN: Cell Census of Developing Brain
Conservation and alteration of mammalian striatal interneurons
core
Authors
Emily K. Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero García, Sean de la O, Siting He, Harsha Sen, Mariana Duhne, Shanti Lindberg, Menygi Song, Matthew T. Schmitz, Karen Sears, Ricardo Mallarino, Joshua D. Berke, Corey C. Harwell, Mercedes F. Paredes, Fenna M. Krienen, Alex A. Pollen
Citation
Corrigan, E., et al. Conservation and alteration of mammalian striatal interneurons. Nature (2025). https://doi.org/10.1038/s41586-025-09592-w
Summary
We survey gene expression from 10 mammalian species, spanning 160 million years of divergence, and discover that TAC3 interneurons, previously thought to be a primate specific population, instead represent a conserved, ancestral population with modified gene expression and distribution throughout evolution. This finding suggests that brain evolution among mammals occurs through fate refinement of initial classes during development, rather than the generation of entirely novel populations.
Data and Tools
Resource Name | Resource URL | Description |
|---|---|---|
Hotspot Code | https://github.com/YosefLab/Hotspot | Code Repository: hotspotsc v1.1.1 code for identifying informative genes and gene modules in a single-cell dataset. |
Github scripts and annotation files | https://github.com/mdeber/Corrigan2024 | Code Repository: python multi-species analysis code. |